Burkholderia pseudomalleiTropism and the Melioidosis Road Map
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چکیده
منابع مشابه
Burkholderia pseudomallei tropism and the melioidosis road map.
Melioidosis, which is caused by the soildwelling gram-negative bacterium Burkholderia pseudomallei, is often called the great mimicker. Disease presentation can range from acute fulminant sepsis to a chronic tuberculosis–like illness [1]. Pneumonia is the most common presentation of melioidosis; however, infection can arise in virtually any organ. It is thought that up to 5% of patients have di...
متن کاملBurkholderia pseudomallei and Burkholderia mallei: Melioidosis and Glanders
The genus Burkholderia is currently composed of many species, but only three are notable pathogens for humans or animals: the former cepacia complex (described in Chapter 220) pseudomallei (the agent of melioidosis), and mallei (the agent of equine glanders). All three are aerobic, nonsporulating, straight or slightly curved gram-negative bacilli that were formerly placed in the genus Pseudomonas.
متن کاملA Proteome Reference Map of the Causative Agent of Melioidosis Burkholderia pseudomallei
Burkholderia pseudomallei is the etiologic agent of melioidosis. Using 2DE and MALDI-TOF MS, we report here a proteome reference map constructed from early stationary phase, a bacterial adaptation process. We identified 282 protein spots representing 220 ORFs; many of them have been implicated in bacterial pathogenesis. Up to 20% of identified ORFs belong to post-translational modification and ...
متن کاملGlobal map of growth-regulated gene expression in Burkholderia pseudomallei, the causative agent of melioidosis.
Many microbial pathogens express specific virulence traits at distinct growth phases. To understand the molecular pathways linking bacterial growth to pathogenicity, we have characterized the growth transcriptome of Burkholderia pseudomallei, the causative agent of melioidosis. Using a fine-scale sampling approach, we found approximately 17% of all B. pseudomallei genes displaying regulated exp...
متن کاملEvolution of Burkholderia pseudomallei in Recurrent Melioidosis
Burkholderia pseudomallei, the etiologic agent of human melioidosis, is capable of causing severe acute infection with overwhelming septicemia leading to death. A high rate of recurrent disease occurs in adult patients, most often due to recrudescence of the initial infecting strain. Pathogen persistence and evolution during such relapsing infections are not well understood. Bacterial cells pre...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2009
ISSN: 0022-1899,1537-6613
DOI: 10.1086/599211